Devising new strategies to track and prevent breast cancer development in BRCA mutation carriers

The overall goal of this project is to better understand the earliest stages of BRCA cancer development, in order to design strategies to prevent its progression to frank cancer. Dr. Joan Brugge’s laboratory studies the mechanisms of cancer initiation, progression, and drug resistance in breast, ovarian and other BRCA-related cancers. Specifically, Brugge’s team investigates tumor heterogeneity, cell-cell interactions, tumor microenvironment, cancer metabolism, drug resistance, and cell signaling using wide collection of tools, including 3D/organoid cell cultures, genetically-engineered and transplantation-based animal models, single-cell analysis, metabolomics, high-throughput microscopy, and other advanced technologies.

Project Overview
Publications
Data Stories
Explore Tissue Images

Project Overview

Breast Cancer Atlas with Dr. Joan Brugge

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Publications

Luminal breast epithelial cells of BRCA1 or BRCA2 mutation carriers and noncarriers harbor common breast cancer copy number alterations.

Williams MJ, Oliphant MUJ, Au V, Liu C, Baril C, O’Flanagan C, Lai D, Beatty S, ... Aparicio, S.

Nature Genetics. 2024 Nov 20; 56(12), 2753–2762. https://doi.org/10.1038/s41588-024-01988-0

PMCID: PMC11631757

Brca1 haploinsufficiency promotes early tumor onset and epigenetic alterations in a mouse model of hereditary breast cancer

Li CM, Cordes A, Oliphant MUJ, Quinn SA, Thomas M, Selfors LM, Silvestri F, Girnius N, ... Brugge JS.

Nature Genetics. 2024 Nov 11; 56(12):2763-277 https://doi.org/10.1038/s41588-024-01958-6

PubMed

A human breast atlas integrating single-cell proteomics and transcriptomics.

Gray GK, Li CM-C, Rosenbluth JM, Selfors LM, Girnius N, Lin J-R, Schackmann RCJ, Goh WL, ... Brugge JS.

Developmental Cell. 2022 Jun 6; 57(11):1400-1420.e7. https://doi.org/10.1016/j.devcel.2022.05.003

PMCID: PMC9202341

Data Stories

Data Stories are data visualizations that guide readers through the complexities of a large dataset through filters, search, or narrated image waypoints.

Processed CNA Data: Single-Cell Copy Number Calls

Primary Sequencing Data: DLP+ Single-Cell Whole Genome Sequencing of Luminal Breast Epithelial Cells from Wildtype and BRCA Mutation Carriers

Summary Report: Single-Cell Copy Number Alteration Overview

Single-Cell human breast atlas integrating single-cell proteomics and transcriptomics

K20 (BRCA mutant) - Narrated

K16 (BRCA mutant) - Narrated

Single-Cell RNA Sequencing of Breast Tissues

Explore Tissue Images

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