The Gray BRCA Pre-Cancer Atlas seeks to transform treatment and prevention for BRCA1/2 mutation-associated cancers through innovative research and new profiling methods.
ADVANCING CANCER RESEARCH
The Gray Foundation is transforming how we identify and study the earliest stages of cancer to enable treatment before the cancer spreads. The Atlas focuses on breast and ovarian cancers and the impact on these diseases of mutations in BRCA1 or BRCA2 genes, which substantially increases the hereditary risk of cancer and also impacts treatment options for spontaneous cancers.
Meet the People Behind the Atlas
Publications & Projects
Multimodal spatial profiling reveals immune suppression and microenvironment remodeling in fallopian tube precursors to high-grade serous ovarian carcinoma.
Explore Data
Publication
Luminal breast epithelial cells of BRCA1 or BRCA2 mutation carriers and noncarriers harbor common breast cancer copy number alterations.
Explore Data
Publication
Brca1 haploinsufficiency promotes early tumor onset and epigenetic alterations in a mouse model of hereditary breast cancer
Publication
H2Bub1 loss is an early contributor to clear cell ovarian cancer progression.
Publication
News
Data
Ovarian STIC Spatial Transcriptomic Data from GeoMX and Multiplex Imaging
Ovarian Cancer with Annotation - LSP15327
Processed CNA Data: Single-Cell Copy Number Calls
Primary Sequencing Data: DLP+ Single-Cell Whole Genome Sequencing of Luminal Breast Epithelial Cells from Wildtype and BRCA Mutation Carriers
Summary Report: Single-Cell Copy Number Alteration Overview
Ovarian Cancer with Annotation - LSP15343
Single-Cell human breast atlas integrating single-cell proteomics and transcriptomics
Single-Cell RNA Sequencing of Breast Tissues
BRCA1-associated-8
BRCA WT vs BRCA1 associated TNBC